Physicochemical Properties

Physicochemical Properties

Physicochemical properties are a key determinant of a drug’s pharmacokinetic and pharmacodynamic profile.

Designing sufficiently drug-like compounds is of pivotal importance to avoid time-consuming and expensive ADME problems during pre-clinical and clinical development.

Whilst molecular weight, charge, polar surface area and the number of hydrogen bond donors/acceptors can be calculated or predicted in silico, lipophilicity and solubility predictions are often more challenging and therefore, require assessment in vitro.

At XenoGesis we offer state-of-the-art determination of the following physicochemical parameters: