Packaged Services

Packaged Services

XenoGesis has created a series of packaged services designed to help make better informed decisions in your drug discovery cascade. To find out more about this easy, one-stop approach, contact a member of the team today.

Description

Predicted hepatic metabolic clearance and metabolite identification


Data collected

Intrinsic clearance in hepatocytes, plasma protein binding, blood:plasma ratio, Fuinc


Report Format

Predicted clearance and maximal unbound drug exposure (AUC) for an oral dose. Proposed structures for most abundant metabolites

Description

Preliminary assessment of absorption potential following an oral dose


Data collected

Caco-2 permeability, thermodynamic solubility


Report Format

Estimates of rate of absorption and maximal absorbable dose following oral administration. Preliminary BCS classification

Description

Integration of Metabolism and Absorption packages


Data collected

All data from “Metabolism” and “Absorption”


Report Format

Integrated report covering outputs from Metabolism and Absorption including predicted oral bioavailability

Description

Interpretation of PK data relative to in vitro pharmacology. Selection of doses for in vivo pharmacology based on PK-PD hypothesis


Data collected

Oral PK, plasma protein binding, cell assay media binding


Report Format

Plot of total and unbound plasma concentration-time profiles. Generation of compartmental PK model and simulation of dose and frequency to achieve desired coverage for PD effect (e.g. trough unbound Cmin > EC90)